Antinociceptive Effect of Methanol Extract of <i>Diospyros malabarica</i> (Desr.) Kostel Leaves in Mice

Background: Diospyros malabarica (Desr.) Kostel, a small to medium-sized tree in the Ebenaceae family, is known as “Deshi Gab” Bangladesh. Fever, diabetes, snake bite, diarrhea, biliousness, and ulcer ailments are all treated with herb. This study’s goal was examine mouse models antinociceptive properties of methanol extract leaves (MEDM). Methods: For purpose determining activity mice, five distinct pain including hot plate, tail immersion, acetic acid-induced writhing, formalin glutamate-induced nociception tests were used. The conventional medications morphine sulphate (5 mg/kg, intraperitoneally) diclofenac sodium (10 intraperitoneally). While control group expecting deionized water, MEDM given orally at dosages 200, 400, 600 mg/kg (0.1 mL/mouse, orally). Results: According current research, strongly reflected chemical heat-induced (*p Conclusions: It evident that plant has exceptional analgesic properties. To determine precise processes behind effect identify substances produce this activity, more research required. findings also support long-standing use painful conditions.